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Article

MTHFR and MTRR Polymorphisms Predict Sex-Dependent Psychotic Symptom Improvements, Not Metabolic Changes.

International journal of molecular sciences - 29 Jan 2026

Nadalin Sergej, Majdandžić Ivan, Vraneković Jadranka, Peitl Vjekoslav, Vilibić Maja, Silić Ante, Karlović Dalibor

Abstract excerpt

We investigated whether antipsychotic treatment response was influenced by the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase (MTHFR), and A66G of methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR)-genes central to folate and homocysteine metabolism and methylation, pathways often altered in schizophrenia patients. To our knowledge, no study has examined associations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41683775
DOI: 10.3390/ijms27031348
PMCID: PMC12898146

Genes

MTRR
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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