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Article

Folate supplementation in schizophrenia: a possible role for MTHFR genotype.

Schizophrenia research - 1 Apr 2011

Hill Michele, Shannahan Kelsey, Jasinski Sarah, Macklin Eric A, Raeke Lisa, Roffman Joshua L, Goff Donald C

Abstract excerpt

BACKGROUND: Folate deficiency and the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism have been linked to negative symptoms in schizophrenia both independently and synergistically. This study examined the effect of folate supplementation on negative symptoms overall and in relation to MTHFR 677C>T genotype. METHOD: Forty-six stable adult schizophrenia outpatients were enrolled and 32 were...

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Source

Identifiers

PMID: 21334854
DOI: 10.1016/j.schres.2010.12.006

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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