Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.

Abstract excerpt

Low serum folate levels previously have been associated with negative symptom risk in schizophrenia, as has the hypofunctional 677C>T variant of the MTHFR gene. This study examined whether other missense polymorphisms in folate-regulating enzymes, in concert with MTHFR, influence negative symptoms in schizophrenia, and whether total risk allele load interacts with serum folate status to further stratify negative...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
• Share to Catechol O-Methyltransferase