Article
Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.
Nature neuroscience - 1 Mar 2001
Lu T, Ting A Y, Mainland J, Jan L Y, Schultz P G, Yang J
Abstract excerpt
Potassium channels selectively conduct K+ ions across cell membranes, and use diverse mechanisms to control their gating. We studied ion permeation and gating of an inwardly rectifying K+ channel by individually changing the amide carbonyls of two conserved glycines lining the selectivity filter to ester carbonyls using nonsense suppression. Surprisingly, these backbone mutations do not significantly alter ion...
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