Article
Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease.
Annals of neurology - 1 Mar 2010
Vemuri Prashanthi, Wiste Heather J, Weigand Stephen D, Knopman David S, Shaw Leslie M, Trojanowski John Q, Aisen Paul S, Weiner Michael, Petersen Ronald C, Jack Clifford R
Abstract excerpt
OBJECTIVE: To study the effect of apolipoprotein E epsilon4 status on biomarkers of neurodegeneration (atrophy on magnetic resonance imaging [MRI]), neuronal injury (cerebrospinal fluid [CSF] t-tau), and brain Abeta amyloid load (CSF Abeta(1-42)) in cognitively normal subjects (CN), amnestic subj...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E4
- Atrophy
- Biomarkers
- Brain
- DNA Mutational Analysis
- Disease Progression
- Female
- Gene Dosage
- Genetic Markers
- Genetic Predisposition to Disease