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Article

Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease.

Annals of neurology - 1 Mar 2010

Vemuri Prashanthi, Wiste Heather J, Weigand Stephen D, Knopman David S, Shaw Leslie M, Trojanowski John Q, Aisen Paul S, Weiner Michael, Petersen Ronald C, Jack Clifford R

Abstract excerpt

OBJECTIVE: To study the effect of apolipoprotein E epsilon4 status on biomarkers of neurodegeneration (atrophy on magnetic resonance imaging [MRI]), neuronal injury (cerebrospinal fluid [CSF] t-tau), and brain Abeta amyloid load (CSF Abeta(1-42)) in cognitively normal subjects (CN), amnestic subjects with mild cognitive impairment (aMCI), and patients with Alzheimer disease (AD). METHODS: We included all 399...

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Identifiers

PMID: 20373342
DOI: 10.1002/ana.21953
PMCID: PMC2886799

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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