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Article

Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2005

Reiman Eric M, Chen Kewei, Alexander Gene E, Caselli Richard J, Bandy Daniel, Osborne David, Saunders Ann M, Hardy John

Abstract excerpt

Patients with Alzheimer's disease (AD) have abnormally low positron emission tomography (PET) measurements of the cerebral metabolic rate for glucose (CMRgl) in regions of the precuneus and the posterior cingulate, parietotemporal, and frontal cortex. Apolipoprotein E (APOE) epsilon4 gene dose (i.e., the number of epsilon4 alleles in a person's APOE genotype) is associated with a higher risk of AD and a younger...

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Source

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Identifiers

PMID: 15932949
DOI: 10.1073/pnas.0500579102
PMCID: PMC1149416

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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