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Article

Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.

JCI insight - 8 Feb 2021

Nitschke Larissa, Coffin Stephanie L, Xhako Eder, El-Najjar Dany B, Orengo James P, Alcala Elizabeth, Dai Yanwan, Wan Ying-Wooi, Liu Zhandong, Orr Harry T, Zoghbi Huda Y

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder characterized by motor incoordination, mild cognitive decline, respiratory dysfunction, and early lethality. It is caused by the expansion of the polyglutamine (polyQ) tract in Ataxin-1 (ATXN1), which stabilizes the protein, leading to its toxic accumulation in neurons. Previously, we showed that serine 776 (S776) phosphorylation is...

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Identifiers

PMID: 33554954
DOI: 10.1172/jci.insight.144955
PMCID: PMC7934855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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