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Article

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.

Neuron - 8 May 2003

Emamian Effat S, Kaytor Michael D, Duvick Lisa A, Zu Tao, Tousey Susan K, Zoghbi Huda Y, Clark H Brent, Orr Harry T

Abstract excerpt

Polyglutamine-induced neurodegeneration in transgenic mice carrying the spinocerebellar ataxia type 1 (SCA1) gene is modulated by subcellular distribution of ataxin-1 and by components of the protein folding/degradation machinery. Since phosphorylation is a prominent mechanism by which these processes are regulated, we examined phosphorylation of ataxin-1 and found that serine 776 (S776) was phosphorylated....

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PMID: 12741986
DOI: 10.1016/s0896-6273(03)00258-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.PMID 12741986Read ↗

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