Article
Requirement of the serine-threonine kinase Akt for heat treatment-induced activation of p70 S6 kinase.
Biochemical and biophysical research communications - 28 Aug 1998
Kuroda S, Ogawa W, Kitamura T, Konishi H, Kikkawa U, Kasuga M
Abstract excerpt
p70 S6 kinase plays an important role in growth factor-induced translational control and in cell cycle progression. Although the mechanism of p70 S6 kinase regulation is not fully understood, phosphorylation of serine and threonine residues of the enzyme is essential for its activation. The possible role of the serine-threonine kinase Akt in the activation of p70 S6 kinase induced by exposure of cells to heat has...
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