Article
Requirement of the serine-threonine kinase Akt for heat treatment-induced activation of p70 S6 kinase.
Biochemical and biophysical research communications - 28 Aug 1998
Kuroda S, Ogawa W, Kitamura T, Konishi H, Kikkawa U, Kasuga M
Abstract excerpt
p70 S6 kinase plays an important role in growth factor-induced translational control and in cell cycle progression. Although the mechanism of p70 S6 kinase regulation is not fully understood, phosphorylation of serine and threonine residues of the enzyme is essential for its activation. The possi...
Topics
- Adenoviridae
- Animals
- Binding Sites
- CHO Cells
- Cricetinae
- Enzyme Activation
- Genetic Vectors
- Hot Temperature
- Mutagenesis, Site-Directed
- Mutation
- Phosphorylation
- Platelet-Derived Growth Factor
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-akt
- Rats
- Recombinant Proteins
- Ribosomal Protein S6 Kinases