The role of the TP53 gene during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.

doi:10.1016/j.etp.2010.03.009

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Article

The role of the TP53 gene during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Jul 2011

Minicucci E M, Ribeiro D A, da Silva G N, Pardini M I M C, Montovani J C, Salvadori D M F

Abstract excerpt

The medium-term tongue carcinogenesis assay is a useful model for studying oral squamous cell carcinomas phase by phase. The aim of the present study was to investigate the expression of p53 by immunohistochemistry and examine the DNA sequence of exons 5, 6, 7, and 8 of Tp53 for mutations during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO). A total of 30 male Wistar rats were treated with...

Topics

4-Nitroquinoline-1-oxide
Animals
Carcinogenicity Tests
Genes, p53
Immunohistochemistry
Male
Mutagens
Mutation
Polymerase Chain Reaction
Rats
Rats, Wistar
Tongue Neoplasms
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 20385474
DOI: 10.1016/j.etp.2010.03.009

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