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Article

p53 +/- Hemizygous Knockout Mouse: Overview of Available Data

1 Jan 2001

Abstract excerpt

The performance of the p53-/- transgenic (knockout) mouse model was evaluated through review of the data from 31 short-term carcinogenicity studies with 21 compounds tested as part of the International Life Sciences Institute's (ILSI) Alternatives to Carcinogenicity Testing (ACT) project, together with data from other studies which used comparable protocols. As expected based on the hypothesis for the model, a...

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PMID: 11695560
DOI: 10.1080/019262301753178465

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