Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.

Toxicology - 8 Feb 2013

Hibi Daisuke, Kijima Aki, Suzuki Yuta, Ishii Yuji, Jin Meilan, Sugita-Konishi Yoshiko, Yanai Tokuma, Nishikawa Akiyoshi, Umemura Takashi

Abstract excerpt

Ochratoxin A (OTA) is a mycotoxin produced by fungal species and is carcinogenic targeting the S3 segment of the renal proximal tubules in rodents. We previously reported that exposure of gpt delta rats to OTA induced both mutations in the red/gam gene (Spi(-)), suggesting large deletion mutations, and fluctuations in genes transcribed by p53 in the kidneys, which were associated with DNA double-strand break...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Kidney Tubules

Share to Mutagenicity Tests

Share to Mutagens

Share to Pentosyltransferases

Share to Recombinational DNA Repair

Source

Identifiers

PMID: 23261758
DOI: 10.1016/j.tox.2012.12.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.PMID 23261758Read ↗

Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice.Semantic proximity Read ↗

Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress.Semantic proximity Read ↗

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitroSemantic proximity Read ↗

Sex- and strain-specific expression of cytochrome P450s in Ochratoxin A-induced genotoxicity and carcinogenicity in ratsSemantic proximity Read ↗

Heavy-ion-induced mutations in the gpt delta transgenic mouse: effect of p53 gene knockout.Semantic proximity Read ↗

The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo.Semantic proximity Read ↗

Possible contribution of 8-hydroxydeoxyguanosine to gene mutations in the kidney DNA of gpt delta rats following potassium bromate treatment.Semantic proximity Read ↗

Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice.Semantic proximity Read ↗

Mutant frequency in comparison to oxidative DNA damage induced by ochratoxin A in L5178Y tk+/- (3.7.2C) mouse lymphoma cells.Semantic proximity Read ↗

Phenolphthalein Induces Thymic Lymphomas Accompanied by Loss of the p53 Wild Type Allele in Heterozygous p53-Deficient (±) MiceSemantic proximity Read ↗

Role of p53 gene in apoptotic repair of genotoxic tissue damage in mice.Semantic proximity Read ↗

Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.