Article
Paraoxonase activity and genetic polymorphisms in northern Han Chinese workers exposed to organophosphate pesticides.
Experimental biology and medicine (Maywood, N.J.) - 1 Feb 2014
Zhang Xiaofeng, Sui Hong, Li Haibo, Zheng Jing, Wang Fengqian, Li Baixiang, Zhang Yang
Abstract excerpt
Paraoxonase (PON1) is one of the major players in the detoxification of organophosphates (OPs). This study presents our investigation into the effect of OPs on serum PON1 activity and the distribution of common PON1 polymorphisms in Han Chinese workers with repeated high exposure to OP pesticides, and the factors modulating PON1 activity. In all, 400 participants, including 180 workers exposed to OP pesticides...
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