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Article

Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases.

Toxicology and applied pharmacology - 1 Nov 2011

Androutsopoulos Vasilis P, Kanavouras Konstantinos, Tsatsakis Aristidis M

Abstract excerpt

Organophosphate pesticides are a class of compounds that are widely used in agricultural and rural areas. Paraoxonase 1 (PON1) is a phase-I enzyme that is involved in the hydrolysis of organophosphate esters. Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Recent discoveries in animal models have revealed the important role of the enzyme...

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Source

Identifiers

PMID: 21864557
DOI: 10.1016/j.taap.2011.08.009

Genes

PON1

Variants

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Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases.PMID 21864557Read ↗

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