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Article

The role of PON1 and CYP2D6 genes in susceptibility to organophosphorus chronic intoxication in Egyptian patients.

Neurotoxicology - 1 Mar 2016

Tawfik Khattab Amr Mohamed, Zayed Abeer Ahmed, Ahmed Asmaa Ismail, AbdelAal Aly Gamaleldin, Mekdad Alaa AbdelHamid

Abstract excerpt

BACKGROUND: Paraoxonase-1 (PON1) activity toward organophosphorus(OP) compounds shows inter-individual variations, rendering the identification of individuals' PON1 allozymes valuable in treating patients suffering from organophosphorus intoxication. One of the most important cytochrome P450 monooxygenases (CYPs) is CYP2D6. The CYP2D6 G1934A polymorphism leads to good, poor or no enzyme activity. Genetic testing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26723569
DOI: 10.1016/j.neuro.2015.12.015

Genes

PON1

Variants

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