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Article

Paraoxonase 1 and cytochrome P450 polymorphisms in susceptibility to acute organophosphorus poisoning in Egyptians.

Neurotoxicology - 1 Dec 2015

Zayed Abeer Ahmed, Ahmed Asmaa Ismail, Khattab Amr Mohamed Tawfik, Mekdad Alaa AbdeHamid, AbdelAal Aly Gamaleldin

Abstract excerpt

BACKGROUND: Organophosphates are the basis of many insecticides, herbicides, and nerve agents. They were listed as highly acutely toxic agents. Findings in knockout mice suggest that paraoxonase 1 may modulate the toxicity resulting from exposure to organophosphorus compounds. In human, there is no enough data about genetic modulation of acute organophosphorus intoxication. CYP2D6 is involved in the metabolism of...

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PMID: 26340881
DOI: 10.1016/j.neuro.2015.08.011

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PON1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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