Article
Domain-swapped dimerization of the HIV-1 capsid C-terminal domain.
Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007
Ivanov Dmitri, Tsodikov Oleg V, Kasanov Jeremy, Ellenberger Tom, Wagner Gerhard, Collins Tucker
Abstract excerpt
Assembly of the HIV and other retroviruses is primarily driven by the oligomerization of the Gag polyprotein, the major viral structural protein capable of forming virus-like particles even in the absence of all other virally encoded components. Several critical determinants of Gag oligomerization are located in the C-terminal domain of the capsid protein (CA-CTD), which encompasses the most conserved segment in...
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