Article
Larger helical populations in peptides derived from the dimerization helix of the capsid protein of HIV-1 results in peptide binding toward regions other than the "hotspot" interface.
Biomacromolecules - 12 Sept 2011
Doménech Rosa, Bocanegra Rebeca, González-Muñiz Rosario, Gómez Javier, Mateu Mauricio G, Neira José L
Abstract excerpt
The C-terminal domain (CTD) of the capsid protein (CA) of HIV-1 participates both in the formation of CA hexamers and in the joining of hexamers through homodimerization to form the viral capsid. Intact CA and the CTD are able to homodimerize with similar affinity (~15 μM); CTD homodimerization involves mainly an α-helical region. We have designed peptides derived from that helix with predicted higher helical...
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