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Article

Structural mobility of the monomeric C-terminal domain of the HIV-1 capsid protein.

The FEBS journal - 1 Jul 2008

Alcaraz Luis A, Del Alamo Marta, Mateu Mauricio G, Neira José L

Abstract excerpt

The capsid protein of HIV-1 (p24) (CA) forms the mature capsid of the human immunodeficiency virus. Capsid assembly involves hexamerization of the N-terminal domain and dimerization of the C-terminal domain of CA (CAC), and both domains constitute potential targets for anti-HIV therapy. CAC homodimerization occurs mainly through its second helix, and it is abolished when its sole tryptophan is mutated to alanine....

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Alanine
Biochemistry
Capsid Proteins
Dimerization
Magnetic Resonance Spectroscopy

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Molecular Conformation

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PMID: 18489586
DOI: 10.1111/j.1742-4658.2008.06478.x

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