Article
The CTLA4+49A/G and CT60 polymorphisms and chronic inflammatory arthropathies in Northern Ireland.
Experimental and molecular pathology - 1 Apr 2006
Suppiah V, O'Doherty C, Heggarty S, Patterson C C, Rooney M, Vandenbroeck K
Abstract excerpt
Rheumatoid and juvenile idiopathic arthritis (RA, JIA) are chronic inflammatory arthropathies with an autoimmune background. The cytotoxic T-lymphocyte antigen-4 (CTLA-4) protein plays a key role in the down-regulation of T cell activation. We analyzed the CTLA4 +49A/G and CT60 polymorphisms in cohorts of Northern Irish RA and JIA patients and healthy control subjects using restriction fragment length...
Topics
- Adolescent
- Alleles
- Antigens, CD
- Antigens, Differentiation
- Arthritis, Rheumatoid
- CTLA-4 Antigen
- Case-Control Studies
- Child
- Female
- Genetic Predisposition to Disease
- Haplotypes