Article
CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis.
Tissue antigens - 1 Jan 1999
Harbo H F, Celius E G, Vartdal F, Spurkland A
Abstract excerpt
The human cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene may be a candidate susceptibility gene in multiple sclerosis (MS). In this study the distribution of the dimorphisms of exon 1 (+49 A/G) and promoter (-318 C/T) regions of the CTLA4 gene was analysed in 296 unrelated Norwegian MS patients and 271 matched controls by polymerase chain reaction and restriction fragment length polymorphism. The...
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