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Article

The selection-mutation-drift theory of synonymous codon usage.

Genetics - 1 Nov 1991

Bulmer M

Abstract excerpt

It is argued that the bias in synonymous codon usage observed in unicellular organisms is due to a balance between the forces of selection and mutation in a finite population, with greater bias in highly expressed genes reflecting stronger selection for efficiency of translation. A population genetic model is developed taking into account population size and selective differences between synonymous codons. A...

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Identifiers

PMID: 1752426
DOI: 10.1093/genetics/129.3.897
PMCID: PMC1204756

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Source receipt: pubmed, retrieved 7 Sept 2026.

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