Article
The selection-mutation-drift theory of synonymous codon usage.
Genetics - 1 Nov 1991
Bulmer M
Abstract excerpt
It is argued that the bias in synonymous codon usage observed in unicellular organisms is due to a balance between the forces of selection and mutation in a finite population, with greater bias in highly expressed genes reflecting stronger selection for efficiency of translation. A population genetic model is developed taking into account population size and selective differences between synonymous codons. A...
Topics
- Amino Acyl-tRNA Synthetases
- Codon
- Escherichia coli
- Genes
- Genetic Code
- Genetics, Population
- Models, Theoretical
- Mutation
- Protein Biosynthesis
- Ribosomal Proteins
- Ribosomes
- Selection, Genetic