Mutation-selection models of codon substitution and their use to estimate selective strengths on codon usage.

Abstract excerpt

Current models of codon substitution are formulated at the levels of nucleotide substitution and do not explicitly consider the separate effects of mutation and selection. They are thus incapable of inferring whether mutation or selection is responsible for evolution at silent sites. Here we implement a few population genetics models of codon substitution that explicitly consider mutation bias and natural...

Topics

• Animals
• Codon
• Humans
• Models, Genetic
• Mutation
• Selection, Genetic