Translational selection frequently overcomes genetic drift in shaping synonymous codon usage patterns in vertebrates.

Abstract excerpt

Synonymous codon usage patterns are shaped by a balance between mutation, drift, and natural selection. To date, detection of translational selection in vertebrates has proven to be a challenging task, obscured by small long-term effective population sizes in larger animals and the existence of isochores in some species. The consensus is that, in such species, natural selection is either completely ineffective at...

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