Synonymous substitution-rate constants in Escherichia coli and Salmonella typhimurium and their relationship to gene expression and selection pressure.

Abstract excerpt

Based on the differences in synonymous codon use between E. coli and S. typhimurium, the synonymous substitution rates can be estimated. In contrast to previous studies on the substitution rates in these two organisms, we use a kinetic model that explicitly takes the selection bias into account....

Topics

• Base Sequence
• Biological Evolution
• Escherichia coli
• Gene Expression
• Genes, Bacterial
• Models, Genetic
• Models, Theoretical
• Molecular Sequence Data
• Mutation
• Salmonella typhimurium
• Selection, Genetic
• Time