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Article

Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007

Klaus Alexandra, Saga Yumiko, Taketo Makoto M, Tzahor Eldad, Birchmeier Walter

Abstract excerpt

Heart formation requires the coordinated recruitment of multiple cardiac progenitor cell populations derived from both the first and second heart fields. In this study, we have ablated the Bmp receptor 1a and the Wnt effector beta-catenin in the developing heart of mice by using MesP1-cre, which acts in early mesoderm progenitors that contribute to both first and second heart fields. Remarkably, the entire...

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Identifiers

PMID: 18000065
DOI: 10.1073/pnas.0703113104
PMCID: PMC2141811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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