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Precardiac organoids form two heart fields via Bmp/Wnt signaling

1 Aug 2018

Abstract excerpt

Abstract The discovery of the first heart field (FHF) and the second heart field (SHF) led us to understand how cardiac lineages and structures arise during development. However, it remains unknown how they are specified. Here, we generate precardiac spheroids with pluripotent stem cells (PSCs) harboring GFP/RFP reporters under the control of FHF/SHF markers, respectively. GFP+ cells and RFP+ cells appear from...

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PMID: 30087351
DOI: 10.1038/s41467-018-05604-8

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