Article
HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population.
Diabetes - 1 Sept 2007
Baschal Erin E, Aly Theresa A, Babu Sunanda R, Fernando Maria S, Yu Liping, Miao Dongmei, Barriga Katherine J, Norris Jill M, Noble Janelle A, Erlich Henry A, Rewers Marian J, Eisenbarth George S
Abstract excerpt
OBJECTIVE: A major goal in genetic studies of type 1A diabetes is prediction of anti-islet autoimmunity and subsequent diabetes in the general population, as >85% of patients do not have a first-degree relative with type 1A diabetes. Given prior association studies, we hypothesized that the strongest candidates for enhancing diabetes risk among DR3-DQB1*0201/DR4-DQB1*0302 individuals would be alleles of DP and...
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