Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom.

The Journal of clinical endocrinology and metabolism - 1 Aug 2004

Lambert A Paul, Gillespie Kathleen M, Thomson Glenys, Cordell Heather J, Todd John A, Gale Edwin A M, Bingley Polly J

Abstract excerpt

The autoimmune disease process leading to childhood-onset type 1 diabetes appears to start in infancy, and decisions on treatment to prevent initiation of autoimmunity will need to be based on genetic susceptibility alone. We set out to quantify the absolute risk associated with human leukocyte antigen (HLA) DRB1-DQA1-DQB1 class II genotypes and to develop strategies for recruitment into primary prevention...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 1
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DQ alpha-Chains

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to ROC Curve

Source

Identifiers

PMID: 15292346
DOI: 10.1210/jc.2003-032084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom.PMID 15292346Read ↗

Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity.Semantic proximity Read ↗

High familial risk and genetic susceptibility in early onset childhood diabetes.Semantic proximity Read ↗

Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young.Semantic proximity Read ↗

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.Semantic proximity Read ↗

Next-generation sequencing reveals additional HLA class I and class II alleles associated with type 1 diabetes and age at onset.Semantic proximity Read ↗

Advances in the prediction and natural history of type 1 diabetes.Semantic proximity Read ↗

Genetics of the HLA region in the prediction of type 1 diabetes.Semantic proximity Read ↗

Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study.Semantic proximity Read ↗

A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes.Semantic proximity Read ↗

Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study.Semantic proximity Read ↗

The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study.Semantic proximity Read ↗

Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.