Article
Extreme genetic risk for type 1A diabetes.
Proceedings of the National Academy of Sciences of the United States of America - 19 Sept 2006
Aly Theresa A, Ide Akane, Jahromi Mohamed M, Barker Jennifer M, Fernando Maria S, Babu Sunanda R, Yu Liping, Miao Dongmei, Erlich Henry A, Fain Pamela R, Barriga Katherine J, Norris Jill M, Rewers Marian J, Eisenbarth George S
Abstract excerpt
Type 1A diabetes (T1D) is an autoimmune disorder the risk of which is increased by specific HLA DR/DQ alleles [e.g., DRB1*03-DQB1*0201 (DR3) or DRB1*04-DQB1*0302 (DR4)]. The genotype associated with the highest risk for T1D is the DR3/4-DQ8 (DQ8 is DQA1*0301, DQB1*0302) heterozygous genotype. We determined HLA-DR and -DQ genotypes at birth and analyzed DR3/4-DQ8 siblings of patients with T1D for...
Topics
- Adolescent
- Child
- Child, Preschool
- Chromosomes, Human, Pair 6
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Genotype
- HLA-DR Antigens
- Haplotypes
- Humans
- Infant
- Islets of Langerhans
- Pedigree