Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?

Diabetes - 1 Apr 2009

Steck Andrea K, Zhang Weiming, Bugawan Teodorica L, Barriga Katherine J, Blair Alan, Erlich Henry A, Eisenbarth George S, Norris Jill M, Rewers Marian J

Abstract excerpt

OBJECTIVE: Specific alleles of non-HLA genes INS, CTLA-4, and PTPN22 have been associated with type 1 diabetes. We examined whether some of these alleles influence development of islet autoimmunity or progression from persistent islet autoimmunity to type 1 diabetes in children with high-risk HLA-DR,DQ genotypes. RESEARCH DESIGN AND METHODS: Since 1993, the Diabetes Autoimmunity Study in the Young (DAISY) has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 2

Share to CTLA-4 Antigen

Share to HLA-DQ Antigens

Share to Islets of Langerhans

Share to Nuclear Family

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Open in PubMed Open full text

Identifiers

PMID: 19188433
DOI: 10.2337/db08-1179
PMCID: PMC2661592

Genes

PTPN22
INS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?PMID 19188433Read ↗

Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.Semantic proximity Read ↗

Association of non-HLA genes with type 1 diabetes autoimmunity.Semantic proximity Read ↗

rs11203203 is associated with type 1 diabetes risk in population pre-screened for high-risk HLA-DR,DQ genotypes.Semantic proximity Read ↗

Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY).Semantic proximity Read ↗

Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers.Semantic proximity Read ↗

Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.Semantic proximity Read ↗

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.Semantic proximity Read ↗

Genetics of type 1 diabetes.Semantic proximity Read ↗

Autoimmune Diabetes From Childhood to Adulthood: The Role of Pancreatic Autoantibodies and HLA-DRB1 Genotype.Semantic proximity Read ↗

Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.Semantic proximity Read ↗

HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity.Semantic proximity Read ↗

Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.