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Article

Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.

Diabetes - 1 Mar 2012

Steck Andrea K, Wong Randall, Wagner Brandie, Johnson Kelly, Liu Edwin, Romanos Jihane, Wijmenga Cisca, Norris Jill M, Eisenbarth George S, Rewers Marian J

Abstract excerpt

We assessed the effects of non-HLA gene polymorphisms on the risk of islet autoimmunity (IA) and progression to type 1 diabetes in the Diabetes Autoimmunity Study in the Young. A total of 1,743 non-Hispanic, white children were included: 861 first-degree relatives and 882 general population child...

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Share to Adaptor Proteins, Signal Transducing
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to HLA-DQ Antigens

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Share to Islets of Langerhans

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Open in PubMed Open full text

Identifiers

PMID: 22315323
DOI: 10.2337/db11-1228
PMCID: PMC3282811

Genes

INS
PTPN22
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22315323-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.PMID 22315323Read ↗

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Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young.Semantic proximity Read ↗

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