Article
Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.
Diabetes - 1 Mar 2016
Zhao Lue Ping, Alshiekh Shehab, Zhao Michael, Carlsson Annelie, Larsson Helena Elding, Forsander Gun, Ivarsson Sten A, Ludvigsson Johnny, Kockum Ingrid, Marcus Claude, Persson Martina, Samuelsson Ulf, Örtqvist Eva, Pyo Chul-Woo, Nelson Wyatt C, Geraghty Daniel E, Lernmark Åke
Abstract excerpt
The possible contribution of HLA-DRB3, -DRB4, and -DRB5 alleles to type 1 diabetes risk and to insulin autoantibody (IAA), GAD65 (GAD autoantibody [GADA]), IA-2 antigen (IA-2A), or ZnT8 against either of the three amino acid variants R, W, or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next-generation sequencing (NGS) was used to determine all DRB alleles in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.