Article
HLA-associated phenotypes in youth with autoimmune diabetes.
Pediatric diabetes - 1 Mar 2013
Black Mary Helen, Lawrence Jean M, Pihoker Catherine, Dolan Lawrence M, Anderson Andrea, Rodriguez Beatriz, Marcovina Santica M, Mayer-Davis Elizabeth J, Imperatore Giuseppina, Dabelea Dana
Abstract excerpt
OBJECTIVES: To examine human leukocyte antigen HLA DRB1-DQB1 haplotypes within a multi-ethnic cohort and assess their association with characteristics of diabetes onset. METHODS: The sample included 1662 participants from the SEARCH for Diabetes in Youth Study who tested positive for GADA and/or IA-2A autoantibodies. Blood drawn at the study visit was used to measure fasting C-peptide (FCP) and genotype HLA DRB1...
Topics
- Adolescent
- Black People
- C-Peptide
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Female
- Genetic Predisposition to Disease
- HLA Antigens
- HLA-DQ beta-Chains
- HLA-DRB1 Chains
- Haplotypes
- Hispanic or Latino