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Article

LRRK2 is a component of granular alpha‐synuclein pathology in the brainstem of Parkinson's disease

26 Oct 2007

Abstract excerpt

Classical Parkinson's disease (PD) is characterized by the appearance of Lewy bodies (LBs) in affected brain regions, showing mostly compact alpha-synuclein deposition, in contrast with punctate or granular deposition, hypothesized to represent early stages of aggregation. Leucine-rich repeat kinase 2 (LRRK2) is the commonest mutated gene in inherited and idiopathic PD. LRRK2 mutation carriers display a diverse...

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PMID: 17971075
DOI: 10.1111/j.1365-2990.2007.00888.x

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