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Article

Expression and localization of Parkinson's disease‐associated leucine‐rich repeat kinase 2 in the mouse brain

2 Oct 2006

Abstract excerpt

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) have been identified as the cause of familial Parkinson's disease (PD) at the PARK8 locus. To begin to understand the physiological role of LRRK2 and its involvement in PD, we have investigated the distribution of LRRK2 mRNA and protein in the adult mouse brain. In situ hybridization studies indicate sites of mRNA expression throughout the mouse...

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PMID: 17101029
DOI: 10.1111/j.1471-4159.2006.04246.x

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