Article
LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study.
Neuropathology and applied neurobiology - 1 Dec 2011
Sharma S, Bandopadhyay R, Lashley T, Renton A E M, Kingsbury A E, Kumaran R, Kallis C, Vilariño-Güell C, O'Sullivan S S, Lees A J, Revesz T, Wood N W, Holton J L
Abstract excerpt
AIMS: Mutations in the gene encoding leucine-rich repeat kinase-2 (LRRK2) have been established as a common genetic cause of Parkinson's disease (PD). The distribution of LRRK2 mRNA and protein in the human brain has previously been described, although it has not been reported in PD cases with the common LRRK2 G2019S mutation. METHODS: To further elucidate the role of LRRK2 in PD, we determined the localization...
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