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Article

Concordance of pharmacogenetic polymorphisms in tumor and germ line DNA in adult patients with acute myeloid leukemia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2007

Weiss Joli R, Baer Maria R, Ambrosone Christine B, Blanco Javier G, Hutson Alan, Ford Laurie A, Moysich Kirsten B

Abstract excerpt

Archived tumor tissue is a useful resource for retrospective studies addressing relationships between genetic polymorphisms and treatment outcomes. However, genotypes determined in tumor and somatic tissues may differ due to cytogenetic and molecular changes associated with malignant transformation and progression. Discordance between germ line and tumor genotypes may be particularly relevant in leukemia because...

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Source

Identifiers

PMID: 17507636
DOI: 10.1158/1055-9965.EPI-06-0964

Genes

GSTM1
GSTT1
CAT
CDA
GPX1
GSTA1
GSTP1
MGMT
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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