Article
CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication.
Blood - 1 Apr 2003
Bowen David T, Frew Marion E, Rollinson Sara, Roddam Philippa L, Dring Ann, Smith Martyn T, Langabeer Stephen E, Morgan Gareth J
Abstract excerpt
The etiology of acute myeloid leukemia (AML) is largely unknown. Biologic and epidemiologic data implicate exogenous toxicants, including cytotoxic drugs, benzene, radiation, and cigarette smoking. Allelic variation in genes encoding enzymes such as NADP(H) quinone oxidoreductase (NQO1) and gluta...
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