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Article

Sequencing of genes of drug response in tumor DNA and implications for precision medicine in cancer patients.

The pharmacogenomics journal - 1 Jul 2023

Gillis Nancy, Etheridge Amy S, Patil Sushant A, Hayes D Neil, Hayward Michele C, Auman J Todd, Parker Joel S, Innocenti Federico

Abstract excerpt

Tumor DNA sequencing is becoming standard-of-care for patient treatment decisions. We evaluated genotype concordance between tumor DNA and genomic DNA from blood and catalogued functional effects of somatic mutations in 21 drug response genes in 752 solid tumor patients. Using a threshold of 10% difference between tumor and blood DNA variant allele fraction (VAF), concordance for heterogenous genotype calls was...

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Identifiers

PMID: 36709390
DOI: 10.1038/s41397-023-00299-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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