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Article

The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia.

Blood - 15 Nov 2002

Seedhouse Claire, Bainton Rowena, Lewis Michael, Harding Alexander, Russell Nigel, Das-Gupta Emma

Abstract excerpt

Polymorphisms in several DNA repair genes have been described. These polymorphisms may affect DNA repair capacity and modulate cancer susceptibility by means of gene-environment interactions. We investigated DNA repair capacity and its association with acute myeloblastic leukemia (AML). We studied polymorphisms in 3 DNA repair genes: XRCC1, XRCC3, and XPD. We also assessed the incidence of a functional...

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Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NAD(P)H Dehydrogenase (Quinone)

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Share to X-ray Repair Cross Complementing Protein 1

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Source

Identifiers

PMID: 12393447
DOI: 10.1182/blood-2002-04-1152

Genes

XRCC1
NQO1
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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