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Article

The G⁵¹⁶T CYP2B6 germline polymorphism affects the risk of acute myeloid leukemia and is associated with specific chromosomal abnormalities.

PloS one - 1 Jan 2014

Daraki Aggeliki, Zachaki Sophia, Koromila Theodora, Diamantopoulou Paraskevi, Pantelias Gabriel E, Sambani Constantina, Aleporou Vasiliki, Kollia Panagoula, Manola Kalliopi N

Abstract excerpt

The etiology of acute myeloid leukemia (AML) underlies the influence of genetic variants in candidate genes. The CYP2B6 enzyme detoxifies many genotoxic xenobiotics, protecting cells from oxidative damage. The CYP2B6 gene is subjected to a single-nucleotide polymorphism (G⁵¹⁶T) with heterozygotes (GT) and homozygotes (TT) presenting decreased enzymatic activity. This case-control study aimed to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24586425
DOI: 10.1371/journal.pone.0088879
PMCID: PMC3933334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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