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Article

Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost.

Journal of virology - 1 May 2005

Fernandez Caroline S, Stratov Ivan, De Rose Robert, Walsh Katrina, Dale C Jane, Smith Miranda Z, Agy Michael B, Hu Shiu-Lok, Krebs Kendall, Watkins David I, O'connor David H, Davenport Miles P, Kent Stephen J

Abstract excerpt

Escape from specific T-cell responses contributes to the progression of human immunodeficiency virus type 1 (HIV-1) infection. T-cell escape viral variants are retained following HIV-1 transmission between major histocompatibility complex (MHC)-matched individuals. However, reversion to wild type can occur following transmission to MHC-mismatched hosts in the absence of cytotoxic T-lymphocyte (CTL) pressure, due...

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Identifiers

PMID: 15827187
DOI: 10.1128/JVI.79.9.5721-5731.2005
PMCID: PMC1082732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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