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Article

Evolution of HIV‐1 in an HLA‐B*57–Positive Patient during Virologic Escape

1 Jun 2007

Abstract excerpt

Elite suppressors maintain normal CD4(+) T cell counts and viral loads of <50 copies of human immunodeficiency virus type 1 (HIV-1) RNA per milliliter of plasma without antiviral therapy. We report here a case of virologic escape in a human leukocyte antigen (HLA)-B*57-positive patient shortly after seroconversion. This escape was associated with the development of mutations in 2 HLA-B*57-restricted CD8(+) T cell...

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PMID: 17538883
DOI: 10.1086/518515

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