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Article

Tertiary mutations stabilize CD8+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus.

Journal of virology - 1 Mar 2014

Burwitz Benjamin J, Wu Helen L, Reed Jason S, Hammond Katherine B, Newman Laura P, Bimber Benjamin N, Nimiyongskul Francesca A, Leon Enrique J, Maness Nicholas J, Friedrich Thomas C, Yokoyama Masaru, Sato Hironori, Matano Tetsuro, O'Connor David H, Sacha Jonah B

Abstract excerpt

Compensatory mutations offset fitness defects resulting from CD8(+) T lymphocyte (CD8(TL))-mediated escape, but their impact on viral evolution following transmission to naive hosts remains unclear. Here, we investigated the reversion kinetics of Gag(181-189)CM9 CD8(TL) escape-associated compensa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24371068
DOI: 10.1128/JVI.03304-13
PMCID: PMC3957937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24371068-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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