Article
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Journal of virology - 1 Jun 2008
Schneidewind Arne, Brockman Mark A, Sidney John, Wang Yaoyu E, Chen Huabiao, Suscovich Todd J, Li Bin, Adam Rahma I, Allgaier Rachel L, Mothé Bianca R, Kuntzen Thomas, Oniangue-Ndza Cesar, Trocha Alicja, Yu Xu G, Brander Christian, Sette Alessandro, Walker Bruce D, Allen Todd M
Abstract excerpt
Control of human immunodeficiency virus type 1 (HIV-1) by HLA-B27-positive subjects has been linked to an immunodominant CD8(+) cytotoxic T-lymphocyte (CTL) response targeting the conserved KK10 epitope (KRWIILGLNK(263-272)) in p24/Gag. Viral escape in KK10 typically occurs through development of an R(264)K substitution in conjunction with the upstream compensatory mutation S(173)A, and the difficulty of the...
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