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Article

Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function.

PLoS genetics - 1 Nov 2008

Kempf Lucas, Nicodemus Kristin K, Kolachana Bhaskar, Vakkalanka Radhakrishna, Verchinski Beth A, Egan Michael F, Straub Richard E, Mattay Venkata A, Callicott Joseph H, Weinberger Daniel R, Meyer-Lindenberg Andreas

Abstract excerpt

PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome). Here, we show in a family-based sample that functional polymorphisms in PRODH are associated with schizophrenia, with protecti...

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Identifiers

PMID: 18989458
DOI: 10.1371/journal.pgen.1000252
PMCID: PMC2573019

Genes

PRODH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18989458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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