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Article

Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2017

Thompson Carlie A, Karelis Jason, Middleton Frank A, Gentile Karen, Coman Ioana L, Radoeva Petya D, Mehta Rashi, Fremont Wanda P, Antshel Kevin M, Faraone Stephen V, Kates Wendy R

Abstract excerpt

22q11.2 deletion syndrome is a neurogenetic disorder resulting in the deletion of over 40 genes. Up to 40% of individuals with 22q11.2DS develop schizophrenia, though little is known about the underlying mechanisms. We hypothesized that allelic variation in functional polymorphisms in seven genes unique to the deleted region would affect lobar brain volumes, which would predict risk for psychosis in youth with...

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Source

Identifiers

PMID: 28139055
DOI: 10.1002/ajmg.b.32515

Genes

COMT
DGCR8
PRODH
ZDHHC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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