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Article

The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression.

Current opinion in hematology - 1 Jul 2002

Chesi Marta, Bergsagel P Leif, Kuehl W Michael

Abstract excerpt

The t(4;14)(p16.3;q32) translocation that occurs uniquely in a subset of multiple myeloma tumors results in ectopic expression of wild-type FGFR3 and enhanced expression of MMSET, a gene that is homologous to the MLL gene that is involved in acute myeloid leukemias. Wild-type FGFR3 appears to be weakly transforming in a hematopoietic murine model, whereas FGFR3 that contains kinase-activating mutations is...

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Share to Cell Transformation, Neoplastic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multiple Myeloma

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Share to Protein-Tyrosine Kinases

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to Receptors, Fibroblast Growth Factor

Share to Translocation, Genetic

Source

Identifiers

PMID: 12042702
DOI: 10.1097/00062752-200207000-00005

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression.PMID 12042702Read ↗

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.Semantic proximity Read ↗

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The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.Semantic proximity Read ↗

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The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid TranscriptsSemantic proximity Read ↗

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3.Semantic proximity Read ↗

MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesisSemantic proximity Read ↗

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