Article
The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression.
Current opinion in hematology - 1 Jul 2002
Chesi Marta, Bergsagel P Leif, Kuehl W Michael
Abstract excerpt
The t(4;14)(p16.3;q32) translocation that occurs uniquely in a subset of multiple myeloma tumors results in ectopic expression of wild-type FGFR3 and enhanced expression of MMSET, a gene that is homologous to the MLL gene that is involved in acute myeloid leukemias. Wild-type FGFR3 appears to be weakly transforming in a hematopoietic murine model, whereas FGFR3 that contains kinase-activating mutations is...
Topics
- Animals
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Neoplastic
- Humans
- Multiple Myeloma
- Mutation
- Protein-Tyrosine Kinases
- Receptor, Fibroblast Growth Factor, Type 3
- Receptors, Fibroblast Growth Factor
- Translocation, Genetic