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Article

Kinase domain activation through gene rearrangement in multiple myeloma.

Leukemia - 1 Nov 2018

Morgan Gareth J, He Jie, Tytarenko Ruslana, Patel Purvi, Stephens Owen W, Zhong Shan, Deshpande Shayu, Bauer Michael, Weinhold Niels, Schinke Carolina, Rasche Leo, Bailey Mark, Ali Siraj, Ross Jeff, Miller Vincent A, Stephens Phillip, Thanendrarajan Sharmilan, Zangari Maurizio, van Rhee Frits, Mughal Tariq, Davies Faith E, Walker Brian A

Abstract excerpt

Chromosomal rearrangements that result in oncogenic kinase activation are present in many solid and hematological malignancies, but none have been reported in multiple myeloma (MM). Here we analyzed 1421 samples from 958 myeloma patients using a targeted assay and detected fusion genes in 1.5% of patients. These fusion genes were in-frame and the majority of them contained kinase domains from either receptor...

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Share to Anaplastic Lymphoma Kinase
Share to Gene Rearrangement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Myeloma

Share to NF-kappa B

Share to Oncogene Proteins, Fusion

Share to Phosphotransferases

Share to Protein Domains

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 29654269
DOI: 10.1038/s41375-018-0108-y
PMCID: PMC6224403

Genes

ALK
BRAF
EML4
FGFR1
MAPK14
NTRK3
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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